Discovery of driver non-coding splice-site-creating mutations in cancer

Non-coding mutations can create splice sites, however the true extent of how such somatic non-coding mutations affect RNA splicing are largely unexplored. Here we use the MiSplice pipeline to analyze 783 cancer cases with WGS data and 9494 cases with WES data, discovering 562 non-coding mutations th...

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Detalles Bibliográficos
Autores principales: Cao, Song, Zhou, Daniel Cui, Oh, Clara, Jayasinghe, Reyka G., Zhao, Yanyan, Yoon, Christopher J., Wyczalkowski, Matthew A., Bailey, Matthew H., Tsou, Terrence, Gao, Qingsong, Malone, Andrew, Reynolds, Sheila, Shmulevich, Ilya, Wendl, Michael C., Chen, Feng, Ding, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642382/
https://www.ncbi.nlm.nih.gov/pubmed/33149122
http://dx.doi.org/10.1038/s41467-020-19307-6

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