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Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia

Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidati...

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Autores principales: Vinhaes, Caian L., Teixeira, Rozana S., Monteiro-Júnior, Jay A. S., Tibúrcio, Rafael, Cubillos-Angulo, Juan M., Arriaga, María B., Sabarin, Adrielle G., de Souza, Amâncio J., Silva, Jacqueline J., Lyra, Isa M., Ladeia, Ana Marice, Andrade, Bruno B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642412/
https://www.ncbi.nlm.nih.gov/pubmed/33149225
http://dx.doi.org/10.1038/s41598-020-76075-5
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author Vinhaes, Caian L.
Teixeira, Rozana S.
Monteiro-Júnior, Jay A. S.
Tibúrcio, Rafael
Cubillos-Angulo, Juan M.
Arriaga, María B.
Sabarin, Adrielle G.
de Souza, Amâncio J.
Silva, Jacqueline J.
Lyra, Isa M.
Ladeia, Ana Marice
Andrade, Bruno B.
author_facet Vinhaes, Caian L.
Teixeira, Rozana S.
Monteiro-Júnior, Jay A. S.
Tibúrcio, Rafael
Cubillos-Angulo, Juan M.
Arriaga, María B.
Sabarin, Adrielle G.
de Souza, Amâncio J.
Silva, Jacqueline J.
Lyra, Isa M.
Ladeia, Ana Marice
Andrade, Bruno B.
author_sort Vinhaes, Caian L.
collection PubMed
description Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidative stress in a case–control study from Brazil. To do so, a panel containing 9 oxidative stress markers was measured in plasma samples from a cohort of 47 SCA cases and 40 healthy children and adolescents. Among the SCA patients, 42.5% were undertaking hydroxyurea. Multidimensional analysis was employed to describe disease phenotypes. Our results demonstrated that SCA is associated with increased levels of oxidative stress markers, suggesting the existence of an unbalanced inflammatory response in peripheral blood. Subsequent analyses revealed that hydroxyurea therapy was associated with diminished oxidative imbalance in SCA patients. Our findings reinforce the idea that SCA is associated with a substantial dysregulation of oxidative responses which may be dampened by treatment with hydroxyurea. If validated by larger prospective studies, our observations argue that reduction of oxidative stress may be a main mechanism through which hydroxyurea therapy attenuates the tissue damage and can contribute to improved clinical outcomes in SCA.
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spelling pubmed-76424122020-11-06 Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia Vinhaes, Caian L. Teixeira, Rozana S. Monteiro-Júnior, Jay A. S. Tibúrcio, Rafael Cubillos-Angulo, Juan M. Arriaga, María B. Sabarin, Adrielle G. de Souza, Amâncio J. Silva, Jacqueline J. Lyra, Isa M. Ladeia, Ana Marice Andrade, Bruno B. Sci Rep Article Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidative stress in a case–control study from Brazil. To do so, a panel containing 9 oxidative stress markers was measured in plasma samples from a cohort of 47 SCA cases and 40 healthy children and adolescents. Among the SCA patients, 42.5% were undertaking hydroxyurea. Multidimensional analysis was employed to describe disease phenotypes. Our results demonstrated that SCA is associated with increased levels of oxidative stress markers, suggesting the existence of an unbalanced inflammatory response in peripheral blood. Subsequent analyses revealed that hydroxyurea therapy was associated with diminished oxidative imbalance in SCA patients. Our findings reinforce the idea that SCA is associated with a substantial dysregulation of oxidative responses which may be dampened by treatment with hydroxyurea. If validated by larger prospective studies, our observations argue that reduction of oxidative stress may be a main mechanism through which hydroxyurea therapy attenuates the tissue damage and can contribute to improved clinical outcomes in SCA. Nature Publishing Group UK 2020-11-04 /pmc/articles/PMC7642412/ /pubmed/33149225 http://dx.doi.org/10.1038/s41598-020-76075-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vinhaes, Caian L.
Teixeira, Rozana S.
Monteiro-Júnior, Jay A. S.
Tibúrcio, Rafael
Cubillos-Angulo, Juan M.
Arriaga, María B.
Sabarin, Adrielle G.
de Souza, Amâncio J.
Silva, Jacqueline J.
Lyra, Isa M.
Ladeia, Ana Marice
Andrade, Bruno B.
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title_full Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title_fullStr Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title_full_unstemmed Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title_short Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
title_sort hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642412/
https://www.ncbi.nlm.nih.gov/pubmed/33149225
http://dx.doi.org/10.1038/s41598-020-76075-5
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