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Broadly Reactive Influenza Antibodies Are Not Limited by Germinal Center Competition with High-Affinity Antibodies

Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodies specific for the variable epitopes are much more prevale...

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Detalles Bibliográficos
Autores principales: Keating, Rachael, Johnson, Jenny L., Brice, David C., Labombarde, Jocelyn G., Dent, Alexander L., McGargill, Maureen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642676/
https://www.ncbi.nlm.nih.gov/pubmed/33144374
http://dx.doi.org/10.1128/mBio.01859-20