Cargando…
Genome Profiling for Aflatoxin B(1) Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B(1)-Associated DNA Damage
Exposure to the mycotoxin aflatoxin B1 (AFB(1)) strongly correlates with hepatocellular carcinoma (HCC). P450 enzymes convert AFB(1) into a highly reactive epoxide that forms unstable 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB(1)-N(7)-Gua) DNA adducts, which convert to stable mutagenic AFB...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642924/ https://www.ncbi.nlm.nih.gov/pubmed/32994210 http://dx.doi.org/10.1534/g3.120.401723 |