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Genome Profiling for Aflatoxin B(1) Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B(1)-Associated DNA Damage

Exposure to the mycotoxin aflatoxin B1 (AFB(1)) strongly correlates with hepatocellular carcinoma (HCC). P450 enzymes convert AFB(1) into a highly reactive epoxide that forms unstable 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB(1)-N(7)-Gua) DNA adducts, which convert to stable mutagenic AFB...

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Detalles Bibliográficos
Autores principales:	St. John, Nick, Freedland, Julian, Baldino, Henri, Doyle, Francis, Cera, Cinzia, Begley, Thomas, Fasullo, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2020
Materias:	Mutant Screen Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642924/ https://www.ncbi.nlm.nih.gov/pubmed/32994210 http://dx.doi.org/10.1534/g3.120.401723

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