Activity of Birinapant, a SMAC Mimetic Compound, Alone or in Combination in NSCLCs With Different Mutations

Liver kinase B1 (LKB1/STK11) is the second tumor suppressor gene most frequently mutated in non-small-cell lung cancer (NSCLC) and its activity is impaired in about half KRAS-mutated NSCLCs. Nowadays, no effective therapies are available for patients having these mutations. To highlight new vulnerab...

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Detalles Bibliográficos
Autores principales: Colombo, Marika, Marabese, Mirko, Vargiu, Giulia, Broggini, Massimo, Caiola, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643013/
https://www.ncbi.nlm.nih.gov/pubmed/33194590
http://dx.doi.org/10.3389/fonc.2020.532292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643013/
https://www.ncbi.nlm.nih.gov/pubmed/33194590
http://dx.doi.org/10.3389/fonc.2020.532292

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