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New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family

New substrates with glutamine in the P1-position are introduced for the assay of peptidases from the C1 papain family, with a general formula of Glp-Phe-Gln-X, where Glp is pyroglutamyl and X is pNA (p-nitroanilide) or AMC (4-amino-7-methylcoumaride). The substrates have a simple structure, and C1 c...

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Detalles Bibliográficos
Autores principales: Filippova, Irina Y., Dvoryakova, Elena A., Sokolenko, Nikolay I., Simonyan, Tatiana R., Tereshchenkova, Valeriia F., Zhiganov, Nikita I., Dunaevsky, Yakov E., Belozersky, Mikhail A., Oppert, Brenda, Elpidina, Elena N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643032/
https://www.ncbi.nlm.nih.gov/pubmed/33195423
http://dx.doi.org/10.3389/fmolb.2020.578758