Cargando…

Discovery and Structural Analysis to Improve the Enantioselectivity of Hydroxynitrile Lyase from Parafontaria laminata Millipedes for (R)-2-Chloromandelonitrile Synthesis

[Image: see text] Hydroxynitrile lyase (HNL) catalyzes the reversible synthesis and degradation of cyanohydrins, which are important synthetic intermediates for fine chemical and pharmaceutical industries. Here, we report the discovery of HNL from Parafontaria laminata (PlamHNL) millipedes, purifica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nuylert, Aem, Nakabayashi, Makoto, Yamaguchi, Takuya, Asano, Yasuhisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643134/ https://www.ncbi.nlm.nih.gov/pubmed/33163773 http://dx.doi.org/10.1021/acsomega.0c03070

Ejemplares similares

Hydroxynitrile lyases from cyanogenic millipedes: molecular cloning, heterologous expression, and whole-cell biocatalysis for the production of (R)-mandelonitrile
por: Yamaguchi, Takuya, et al.
Publicado: (2018)

R‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis—A new entry to the carrier protein family Lipocalines
por: Motojima, Fumihiro, et al.
Publicado: (2020)

Four Pristionchus species associated with two mass-occurring Parafontaria laminata populations
por: Kanzaki, Natsumi, et al.
Publicado: (2020)

Structural characterization of Linum usitatissimum hydroxynitrile lyase: A new cyanohydrin decomposition mechanism involving a cyano-zinc complex
por: Zheng, Daijun, et al.
Publicado: (2022)

Identification of saturated and unsaturated 1-methoxyalkanes from the Thai millipede Orthomorpha communis as potential “Raincoat Compounds”
por: Nuylert, Aem, et al.
Publicado: (2018)

Activity and Enantioselectivity of the Hydroxynitrile Lyase MeHNL in Dry Organic Solvents
por: Paravidino, Monica, et al.
Publicado: (2010)

Protein evolution analysis of S-hydroxynitrile lyase by complete sequence design utilizing the INTMSAlign software
por: Nakano, Shogo, et al.
Publicado: (2015)

Discovery of a novel (R)-selective bacterial hydroxynitrile lyase from Acidobacterium capsulatum
por: Wiedner, Romana, et al.
Publicado: (2014)

Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily
por: Lanfranchi, Elisa, et al.
Publicado: (2017)

Erratum: Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily
por: Lanfranchi, Elisa, et al.
Publicado: (2017)

Hydroxynitrile Lyases with α/β-Hydrolase Fold: Two Enzymes with Almost Identical 3D Structures but Opposite Enantioselectivities and Different Reaction Mechanisms
por: Andexer, Jennifer N, et al.
Publicado: (2012)

Progress in Stereoselective Construction of C–C Bonds Enabled by Aldolases and Hydroxynitrile Lyases
por: Liu, Mi, et al.
Publicado: (2021)

Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity
por: Jones, Bryan J., et al.
Publicado: (2020)

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase
por: Casadevall, Guillem, et al.
Publicado: (2023)

A novel cytochrome P450, CYP3201B1, is involved in (R)‐mandelonitrile biosynthesis in a cyanogenic millipede
por: Yamaguchi, Takuya, et al.
Publicado: (2017)

Overexpression of Hydroxynitrile Lyase in Cassava Roots Elevates Protein and Free Amino Acids while Reducing Residual Cyanogen Levels
por: Narayanan, Narayanan N., et al.
Publicado: (2011)

A sacrificial millipede altruistically protects its swarm using a drone blood enzyme, mandelonitrile oxidase
por: Ishida, Yuko, et al.
Publicado: (2016)

Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity(,)
por: Dreveny, Ingrid, et al.
Publicado: (2009)

The cyanogenic syndrome in rubber tree Hevea brasiliensis: tissue-damage-dependent activation of linamarase and hydroxynitrile lyase accelerates hydrogen cyanide release
por: Kadow, Daniel, et al.
Publicado: (2012)

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners
por: Zhang, Jielin, et al.
Publicado: (2019)

Robust, site-specifically immobilized phenylalanine ammonia-lyases for the enantioselective ammonia addition of cinnamic acids
por: Boros, Krisztina, et al.
Publicado: (2021)

Complete Genome Sequence of an Aldoxime Degrader, Bacillus sp. OxB-1
por: Yamaguchi, Takuya, et al.
Publicado: (2015)

Draft Genome Sequence of an Aldoxime Degrader, Rhodococcus sp. Strain YH3-3
por: Yamaguchi, Takuya, et al.
Publicado: (2016)

Discovery and Development of the Enantioselective Minisci Reaction
por: Bacoş, P. David, et al.
Publicado: (2023)

Diversified glucosinolate metabolism: biosynthesis of hydrogen cyanide and of the hydroxynitrile glucoside alliarinoside in relation to sinigrin metabolism in Alliaria petiolata
por: Frisch, Tina, et al.
Publicado: (2015)

Discovery of Novel Tyrosine Ammonia Lyases for the Enzymatic Synthesis of p‐Coumaric Acid
por: Brack, Yannik, et al.
Publicado: (2022)

An archived taxonomic website: Millipedes of Australia
por: Mesibov, Robert Evan
Publicado: (2019)

Millipede accident with unusual dermatological lesion()()
por: Pennini, Silmara Navarro, et al.
Publicado: (2019)

Intraspecific variation and phylogeography of the millipede model organism, the Black Pill Millipede Glomerismarginata (Villers, 1789) (Diplopoda, Glomerida, Glomeridae)
por: Reip, Hans S., et al.
Publicado: (2018)

Strategies for discovery and improvement of enzyme function: state of the art and opportunities
por: Kaul, Praveen, et al.
Publicado: (2012)

A remarkable case of mosaic parapatry in millipedes
por: Mesibov, Robert
Publicado: (2011)

The millipede family Cryptodesmidae in Indochina (Diplopoda, Polydesmida)
por: Golovatch, Sergei I.
Publicado: (2016)

A checklist of the millipedes of Georgia, Caucasus (Diplopoda)
por: Kokhia, Mzia S., et al.
Publicado: (2018)

Diversity and distribution of the millipedes (Diplopoda) of Georgia, Caucasus
por: Kokhia, Mzia S., et al.
Publicado: (2020)

Eight-year periodical outbreaks of the train millipede
por: Niijima, Keiko, et al.
Publicado: (2021)

The first true millipede—1306 legs long
por: Marek, Paul E., et al.
Publicado: (2021)

Deletion of biosynthetic genes, specific SNP patterns and differences in transcript accumulation cause variation in hydroxynitrile glucoside content in barley cultivars
por: Ehlert, Marcus, et al.
Publicado: (2019)

A review of the millipede genus Sinocallipus Zhang, 1993 (Diplopoda, Callipodida, Sinocallipodidae), with notes on gonopods monotony vs. peripheral diversity in millipedes
por: Stoev, Pavel, et al.
Publicado: (2011)

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes
por: Weise, Nicholas J., et al.
Publicado: (2017)

Discovery of a Novel Inhibitor Structure of Mycobacterium tuberculosis Isocitrate Lyase
por: Duan, Changyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9eumg8dp287bn8g3801ovrluvp