Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

BACKGROUND: Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype, which act as a critical mediator of neuroinflammation. Sestrin2 has pro-survival properties against ische...

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Detalles Bibliográficos
Autores principales: He, Tingting, Li, Wanlu, Song, Yaying, Li, Zongwei, Tang, Yaohui, Zhang, Zhijun, Yang, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643276/
https://www.ncbi.nlm.nih.gov/pubmed/33153476
http://dx.doi.org/10.1186/s12974-020-01987-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643276/
https://www.ncbi.nlm.nih.gov/pubmed/33153476
http://dx.doi.org/10.1186/s12974-020-01987-y

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