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Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

BACKGROUND: Neuroinflammation is the major pathogenesis of cerebral ischemia. Microglia are activated and polarized to either the pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype, which act as a critical mediator of neuroinflammation. Sestrin2 has pro-survival properties against ische...

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Detalles Bibliográficos
Autores principales:	He, Tingting, Li, Wanlu, Song, Yaying, Li, Zongwei, Tang, Yaohui, Zhang, Zhijun, Yang, Guo-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643276/ https://www.ncbi.nlm.nih.gov/pubmed/33153476 http://dx.doi.org/10.1186/s12974-020-01987-y

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