The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma

BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of high‐risk disease and poor prognosis. Although less frequent, overexpression of MYC is similarly an indicator of poor prognosis. Most NB tum...

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Detalles Bibliográficos
Autores principales: Maser, Tyler, Zagorski, Joseph, Kelly, Shannon, Ostrander, Anna, Goodyke, Austin, Nagulapally, Abhinav, Bond, Jeffrey, Park, Yeonhee, Saulnier Sholler, Giselle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643634/
https://www.ncbi.nlm.nih.gov/pubmed/33034426
http://dx.doi.org/10.1002/cam4.3407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643634/
https://www.ncbi.nlm.nih.gov/pubmed/33034426
http://dx.doi.org/10.1002/cam4.3407

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