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Quantitative comparison between sub-millisecond time resolution single-molecule FRET measurements and 10-second molecular simulations of a biosensor protein

Molecular Dynamics (MD) simulations seek to provide atomic-level insights into conformationally dynamic biological systems at experimentally relevant time resolutions, such as those afforded by single-molecule fluorescence measurements. However, limitations in the time scales of MD simulations and t...

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Detalles Bibliográficos
Autores principales: Girodat, Dylan, Pati, Avik K., Terry, Daniel S., Blanchard, Scott C., Sanbonmatsu, Karissa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643941/
https://www.ncbi.nlm.nih.gov/pubmed/33151943
http://dx.doi.org/10.1371/journal.pcbi.1008293