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Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial

BACKGROUND: Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the relationships between maternal dysglycaemia at 24 t...

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Detalles Bibliográficos
Autores principales: Antoun, Elie, Kitaba, Negusse T., Titcombe, Philip, Dalrymple, Kathryn V., Garratt, Emma S., Barton, Sheila J., Murray, Robert, Seed, Paul T., Holbrook, Joanna D., Kobor, Michael S., Lin, David TS, MacIsaac, Julia L., Burdge, Graham C., White, Sara L., Poston, Lucilla, Godfrey, Keith M., Lillycrop, Karen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643947/
https://www.ncbi.nlm.nih.gov/pubmed/33151971
http://dx.doi.org/10.1371/journal.pmed.1003229