Rituximab-specific DNA aptamers are able to selectively recognize heat-treated antibodies

The monoclonal anti-CD20 IgG1 antibody rituximab is used as a first-line treatment for B cell lymphoma. Like all therapeutic antibodies, it is a complex protein for which both safety and efficacy heavily depend on the integrity of its three-dimensional structure. Aptamers, short oligonucleotides wit...

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Detalles Bibliográficos
Autores principales: Kohlberger, Michael, Wildner, Sabrina, Regl, Christof, Huber, Christian G., Gadermaier, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644011/
https://www.ncbi.nlm.nih.gov/pubmed/33151990
http://dx.doi.org/10.1371/journal.pone.0241560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644011/
https://www.ncbi.nlm.nih.gov/pubmed/33151990
http://dx.doi.org/10.1371/journal.pone.0241560

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