Cargando…

High prevalence and extended deletions in Plasmodium falciparum hrp2/3 genomic loci in Ethiopia

Deletions in Plasmodium falciparum histidine rich protein 2(pfhrp2) gene threaten the usefulness of the most widely used HRP2-based malaria rapid diagnostic tests (mRDTs) that cross react with its structural homologue, PfHRP3. Parasites with deleted pfhrp2/3 genes remain undetected and untreated due...

Descripción completa

Detalles Bibliográficos
Autores principales:	Golassa, Lemu, Messele, Alebachew, Amambua-Ngwa, Alfred, Swedberg, Gote
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644029/ https://www.ncbi.nlm.nih.gov/pubmed/33152025 http://dx.doi.org/10.1371/journal.pone.0241807

Ejemplares similares

Sequence analysis of Plasmodium vivax Duffy binding proteins reveals the presence of unique haplotypes and diversifying selection in Ethiopian isolates
por: Golassa, Lemu, et al.
Publicado: (2021)

Temporal dynamics of Plasmodium falciparum population in Metehara, east-central Ethiopia
por: Reda, Abeba Gebretsadik, et al.
Publicado: (2022)

Microscopic and molecular evidence of the presence of asymptomatic Plasmodium falciparum and Plasmodium vivax infections in an area with low, seasonal and unstable malaria transmission in Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2015)

Detection of a substantial number of sub-microscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2013)

Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2015)

Correction to: Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2018)

Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions
por: Tadele, Geletta, et al.
Publicado: (2022)

Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia: its impact on the performance of malaria rapid diagnostic tests
por: Alemayehu, Gezahegn Solomon, et al.
Publicado: (2021)

High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2014)

The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health
por: Golassa, Lemu, et al.
Publicado: (2020)

Identification of large variation in pfcrt, pfmdr-1 and pfubp-1 markers in Plasmodium falciparum isolates from Ethiopia and Tanzania
por: Golassa, Lemu, et al.
Publicado: (2015)

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia
por: Tadele, Geletta, et al.
Publicado: (2023)

Large differences in variability for genes associated with antimalarial drug resistance between samples from Tanzania and Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2014)

A retrospective analysis on the transmission of Plasmodium falciparum and Plasmodium vivax: the case of Adama City, East Shoa Zone, Oromia, Ethiopia
por: File, Temesgen, et al.
Publicado: (2019)

Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia: implication for malaria diagnosis
por: Alemayehu, Gezahegn Solomon, et al.
Publicado: (2021)

HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions
por: Kong, Amy, et al.
Publicado: (2021)

Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia
por: Abera, Deriba, et al.
Publicado: (2021)

Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa
por: Watson, Oliver J, et al.
Publicado: (2017)

Plasmodium falciparum Clinical Isolates Reveal Analogous Circulation of 3D7 and FC27 Allelic Variants and Multiplicity of Infection in Urban and Rural Settings: The Case of Adama and Its Surroundings, Oromia, Ethiopia
por: File, Temesgen, et al.
Publicado: (2022)

Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms
por: Kebede, Alebachew Messele, et al.
Publicado: (2019)

Detection of high frequency of MAD20 allelic variants of Plasmodium falciparum merozoite surface protein 1 gene from Adama and its surroundings, Oromia, Ethiopia
por: File, Temesgen, et al.
Publicado: (2021)

High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy
por: Vera-Arias, Claudia A, et al.
Publicado: (2022)

Plasmodium falciparum merozoite invasion ligands, linked antimalarial resistance loci and ex vivo responses to antimalarials in The Gambia
por: Mbye, Haddijatou, et al.
Publicado: (2022)

Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum
por: Oyebola, Kolapo M., et al.
Publicado: (2017)

Genome-wide SNP analysis of Plasmodium falciparum shows differentiation at drug-resistance-associated loci among malaria transmission settings in southern Mali
por: Coulibaly, Aoua, et al.
Publicado: (2022)

Multiplication rate variation in the human malaria parasite Plasmodium falciparum
por: Murray, Lee, et al.
Publicado: (2017)

Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria
por: Tola, Monday, et al.
Publicado: (2020)

Population-level estimates of the proportion of Plasmodium vivax blood-stage infections attributable to relapses among febrile patients attending Adama Malaria Diagnostic Centre, East Shoa Zone, Oromia, Ethiopia
por: Golassa, Lemu, et al.
Publicado: (2017)

Genetic Diversity of Merozoite Surface Protein-1 and -2 Genes in Plasmodium falciparum Isolates among Asymptomatic Population in Boset and Badewacho Districts, Southern Ethiopia
por: Chekol, Tsegaye, et al.
Publicado: (2022)

Significant number of Plasmodium vivax mono-infections by PCR misidentified as mixed infections (P. vivax/P. falciparum) by microscopy and rapid diagnostic tests: malaria diagnostic challenges in Ethiopia
por: Abebe, Abnet, et al.
Publicado: (2023)

PERSISTENCE OF PLASMODIUM FALCIPARUM HRP2 ANTIGEN AFTER EFFECTIVE ANTIMALARIAL THERAPY
por: Michael, O.S., et al.
Publicado: (2021)

Population genetic analysis of the Plasmodium falciparum circumsporozoite protein in two distinct ecological regions in Ghana
por: Amegashie, Elikplim A., et al.
Publicado: (2020)

Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study
por: Kreidenweiss, Andrea, et al.
Publicado: (2019)

Plasmodium falciparum Merozoite Surface Proteins Polymorphisms and Treatment Outcomes among Patients with Uncomplicated Malaria in Mwanza, Tanzania
por: Marwa, Karol J., et al.
Publicado: (2022)

Modelling the epidemiology of malaria and spread of HRP2-negative Plasmodium falciparum following the replacement of HRP2-detecting rapid diagnostic tests
por: Chaudhry, Alisha, et al.
Publicado: (2022)

Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population
por: Amambua-Ngwa, Alfred, et al.
Publicado: (2016)

Genetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource-limited sub-Saharan Africa?
por: Apinjoh, Tobias O., et al.
Publicado: (2019)

Artemether–lumefantrine and dihydroartemisinin–piperaquine treatment outcomes among children infected with uncomplicated Plasmodium falciparum malaria in Mwanza, Tanzania
por: Marwa, Karol J., et al.
Publicado: (2021)

Population genetic structure of Plasmodium falciparum across a region of diverse endemicity in West Africa
por: Mobegi, Victor A, et al.
Publicado: (2012)

Diagnostic performance of NxTek(™) Eliminate Malaria-Pf test for the detection of Plasmodium falciparum in school children with asymptomatic malaria
por: Biruksew, Abdissa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s0mja1rlddmf7s2md5csmro2k3