Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9

The Rag GTPases (Rags) recruit mTORC1 to the lysosomal membrane in response to nutrients, where it is then activated in response to energy and growth factor availability. The lysosomal folliculin (FLCN) complex (LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN...

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Detalles Bibliográficos
Autores principales: Fromm, Simon A., Lawrence, Rosalie E., Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644641/
https://www.ncbi.nlm.nih.gov/pubmed/32868926
http://dx.doi.org/10.1038/s41594-020-0490-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644641/
https://www.ncbi.nlm.nih.gov/pubmed/32868926
http://dx.doi.org/10.1038/s41594-020-0490-9

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