Cargando…

A protein assembly mediates Xist localization and gene silencing

Nuclear compartments play diverse roles in regulating gene expression, yet the molecular forces and components driving compartment formation remain largely unclear(1). The long non-coding RNA Xist establishes an intra-chromosomal compartment by localizing at a high concentration in a territory spati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandya-Jones, Amy, Markaki, Yolanda, Serizay, Jacques, Chitiashvili, Tsotne, Mancia, Walter, Damianov, Andrey, Chronis, Costantinos, Papp, Bernadett, Chen, Chun-Kan, McKee, Robin, Wang, Xiao-Jun, Chau, Anthony, Sabri, Shan, Leonhardt, Heinrich, Zheng, Sika, Guttman, Mitchell, Black, Douglas. L., Plath, Kathrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644664/ https://www.ncbi.nlm.nih.gov/pubmed/32908311 http://dx.doi.org/10.1038/s41586-020-2703-0

Ejemplares similares

FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes
por: Chitiashvili, Tsotne, et al.
Publicado: (2022)

The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3
por: McHugh, Colleen A., et al.
Publicado: (2015)

Developmental Xist induction is mediated by enhanced splicing
por: Stork, Cheryl, et al.
Publicado: (2019)

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
por: Chitiashvili, Tsotne, et al.
Publicado: (2020)

Identification of a Xist silencing domain by Tiling CRISPR
por: Wang, Yang, et al.
Publicado: (2019)

Progress toward understanding chromosome silencing by Xist RNA
por: Brockdorff, Neil, et al.
Publicado: (2020)

Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation
por: Tang, Y Amy, et al.
Publicado: (2010)

Linking Chromosomal Silencing With Xist Expression From Autosomal Integrated Transgenes
por: Naciri, Ikrame, et al.
Publicado: (2021)

Active Chromatin Marks Are Retained on X Chromosomes Lacking Gene or Repeat Silencing Despite XIST/Xist Expression in Somatic Cell Hybrids
por: Thorogood, Nancy P., et al.
Publicado: (2010)

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
por: Smeets, Daniel, et al.
Publicado: (2014)

Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST
por: Kelsey, Angela D., et al.
Publicado: (2015)

Upregulation of long noncoding RNA Xist promotes proliferation of osteosarcoma by epigenetic silencing of P21
por: Xu, Tianyang, et al.
Publicado: (2017)

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features
por: Barros de Andrade e Sousa, Lisa, et al.
Publicado: (2019)

Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
por: Chiang, Jen-Chieh, et al.
Publicado: (2018)

Stochastic gene expression and chromosome interactions in protecting the human active X from silencing by XIST
por: Migeon, Barbara R.
Publicado: (2021)

Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
por: Dixon-McDougall, Thomas, et al.
Publicado: (2022)

Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing
por: Valledor, Melvys, et al.
Publicado: (2023)

TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency
por: Tao, Yu, et al.
Publicado: (2017)

The role of lncRNAs and XIST in oral cancer
por: Liu, Huimin, et al.
Publicado: (2022)

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
por: Loda, Agnese, et al.
Publicado: (2017)

Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke
por: Wang, Cong, et al.
Publicado: (2021)

The B-side of Xist
por: Monfort, Asun, et al.
Publicado: (2020)

Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system
por: Anton, Tobias, et al.
Publicado: (2014)

XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
por: Minks, Jakub, et al.
Publicado: (2013)

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin
por: Xu, Xiaohui, et al.
Publicado: (2020)

Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome
por: Yamada, Norishige, et al.
Publicado: (2015)

The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation
por: Ha, Norbert, et al.
Publicado: (2021)

Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
por: Bowness, Joseph S., et al.
Publicado: (2022)

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing
por: Moindrot, Benoit, et al.
Publicado: (2015)

Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis
por: Yang, Tianqi, et al.
Publicado: (2022)

Xist regulation and function eXplored
por: Pontier, Daphne B., et al.
Publicado: (2011)

Structural modularity of the XIST ribonucleoprotein complex
por: Lu, Zhipeng, et al.
Publicado: (2020)

Evolution from XIST-Independent to XIST-Controlled X-Chromosome Inactivation: Epigenetic Modifications in Distantly Related Mammals
por: Chaumeil, Julie, et al.
Publicado: (2011)

hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing
por: Pintacuda, Greta, et al.
Publicado: (2017)

Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient
por: Ahn, Janice Y, et al.
Publicado: (2010)

Misbehaviour of XIST RNA in Breast Cancer Cells
por: Sirchia, Silvia M., et al.
Publicado: (2009)

Aurora B answers an XIST-ential question
por: Short, Ben
Publicado: (2009)

Xist RNA in action: Past, present, and future
por: Loda, Agnese, et al.
Publicado: (2019)

Silencing of HuR Inhibits Osteosarcoma Cell Epithelial-Mesenchymal Transition via AGO2 in Association With Long Non-Coding RNA XIST
por: Liu, Yongming, et al.
Publicado: (2021)

Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression
por: Ohhata, Tatsuya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ovgf0m3hsc28spdo8lc0vjj447