Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

The minor spliceosome is evolutionarily conserved in higher eukaryotes, but its biological significance remains poorly understood. Here, by precise CRISPR/Cas9-mediated disruption of the U12 and U6atac snRNAs, we report that a defective minor spliceosome is responsible for spinal muscular atrophy (S...

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Detalles Bibliográficos
Autores principales: Li, Liang, Ding, Zhan, Pang, Ting-Lin, Zhang, Bei, Li, Chen-Hui, Liang, An-Min, Wang, Yu-Ru, Zhou, Yu, Fan, Yu-Jie, Xu, Yong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644725/
https://www.ncbi.nlm.nih.gov/pubmed/33154379
http://dx.doi.org/10.1038/s41467-020-19451-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644725/
https://www.ncbi.nlm.nih.gov/pubmed/33154379
http://dx.doi.org/10.1038/s41467-020-19451-z

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