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Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

The minor spliceosome is evolutionarily conserved in higher eukaryotes, but its biological significance remains poorly understood. Here, by precise CRISPR/Cas9-mediated disruption of the U12 and U6atac snRNAs, we report that a defective minor spliceosome is responsible for spinal muscular atrophy (S...

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Detalles Bibliográficos
Autores principales:	Li, Liang, Ding, Zhan, Pang, Ting-Lin, Zhang, Bei, Li, Chen-Hui, Liang, An-Min, Wang, Yu-Ru, Zhou, Yu, Fan, Yu-Jie, Xu, Yong-Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644725/ https://www.ncbi.nlm.nih.gov/pubmed/33154379 http://dx.doi.org/10.1038/s41467-020-19451-z

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