Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells

PURPOSE: The lamina cribrosa (LC) is a key site of damage in glaucomatous optic neuropathy. We previously found that glaucoma LC cells have an increased profibrotic gene expression, with mitochondrial dysfunction in the form of decreased mitochondrial membrane potential. Altered cell bioenergetics h...

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Detalles Bibliográficos
Autores principales: Kamel, Khalid, O'Brien, Colm J., Zhdanov, Alexander V., Papkovsky, Dmitri B., Clark, Abbot F., Stamer, Daniel, Irnaten, Mustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645202/
https://www.ncbi.nlm.nih.gov/pubmed/33137197
http://dx.doi.org/10.1167/iovs.61.13.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645202/
https://www.ncbi.nlm.nih.gov/pubmed/33137197
http://dx.doi.org/10.1167/iovs.61.13.4

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