Mitochondrial dysfunction contributes to Rapamycin-induced apoptosis of Human Glioblastoma Cells - A synergistic effect with Temozolomide

Mammalian target of rapamycin (mTOR) is upregulated in a high percentage of glioblastomas. While a well-known mTOR inhibitor, rapamycin, has been shown to reduce glioblastoma survival, the role of mitochondria in achieving this therapeutic effect is less well known. Here, we examined mitochondrial d...

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Detalles Bibliográficos
Autores principales: Zimmerman, Mary A, Wilkison, Samantha, Qi, Qi, Chen, Guisheng, Li, P. Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645350/
https://www.ncbi.nlm.nih.gov/pubmed/33162811
http://dx.doi.org/10.7150/ijms.40159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645350/
https://www.ncbi.nlm.nih.gov/pubmed/33162811
http://dx.doi.org/10.7150/ijms.40159

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