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Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environment for self-replication and survival. For invasion to occur, the parasite must engage several ligands on the host erythrocyte surface to enable adhesion, tight junction...

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Detalles Bibliográficos
Autores principales: Sleebs, Brad E., Jarman, Kate E., Frolich, Sonja, Wong, Wilson, Healer, Julie, Dai, Weiwen, Lucet, Isabelle S., Wilson, Danny W., Cowman, Alan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645381/
https://www.ncbi.nlm.nih.gov/pubmed/33152623
http://dx.doi.org/10.1016/j.ijpddr.2020.10.008