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Evidence for a non-stochastic two-field hypothesis for persistent skin cancer risk
With recurring carcinogen exposures, individual tumors develop in a field of genetic mutations through a stepwise process of clonal expansion and evolution. Once established, this “cancer field” persists in the absence of continued carcinogen exposures, resulting in a sustained risk for cancer devel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645611/ https://www.ncbi.nlm.nih.gov/pubmed/33154396 http://dx.doi.org/10.1038/s41598-020-75864-2 |