Molecular basis of CTCF binding polarity in genome folding

Current models propose that boundaries of mammalian topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. While the orientation of CTCF motifs determines which pairs of CTCF sites preferentially stabilize loops, the molec...

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Detalles Bibliográficos
Autores principales: Nora, Elphège P., Caccianini, Laura, Fudenberg, Geoffrey, So, Kevin, Kameswaran, Vasumathi, Nagle, Abigail, Uebersohn, Alec, Hajj, Bassam, Saux, Agnès Le, Coulon, Antoine, Mirny, Leonid A., Pollard, Katherine S., Dahan, Maxime, Bruneau, Benoit G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645679/
https://www.ncbi.nlm.nih.gov/pubmed/33154377
http://dx.doi.org/10.1038/s41467-020-19283-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645679/
https://www.ncbi.nlm.nih.gov/pubmed/33154377
http://dx.doi.org/10.1038/s41467-020-19283-x

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