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Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis

Background: Acute gouty arthritis is a common inflammatory arthropathy resulting from urate deposition in joints during persistent hyperuricemia. Nevertheless, effective therapeutic strategies are still unavailable. Here, we propose the crucial role of bromodomain-containing protein 4 (BRD4) in acut...

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Detalles Bibliográficos
Autores principales: Hao, Kun, Jiang, Wenjiao, Zhou, Mengze, Li, Hanwen, Chen, Yadong, Jiang, Fei, Hu, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645998/
https://www.ncbi.nlm.nih.gov/pubmed/33162822
http://dx.doi.org/10.7150/ijbs.46153