Cargando…

FLRT2 functions as Tumor Suppressor gene inactivated by promoter methylation in Colorectal Cancer

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epigenetic alterations, especially DNA methylation, contribute to the initiation and progression of CRC. To identify novel methylated tumor suppressors in CRC, MethylRAD-Seq screening was performed. As the result, FLRT2 was found...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Xiaohong, Song, Chao, Fang, Lei, Li, Min, Yue, Longtao, Sun, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646184/ https://www.ncbi.nlm.nih.gov/pubmed/33193897 http://dx.doi.org/10.7150/jca.47558

Ejemplares similares

Critical Role of FLRT1 Phosphorylation in the Interdependent Regulation of FLRT1 Function and FGF Receptor Signalling
por: Wheldon, Lee M., et al.
Publicado: (2010)

Structural Basis of Latrophilin-FLRT Interaction
por: Jackson, Verity A., et al.
Publicado: (2015)

Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells
por: Bae, Hansol, et al.
Publicado: (2017)

Loss of flrt2 gene leads to microphthalmia in zebrafish
por: Yang, Siyu, et al.
Publicado: (2023)

CFTR Functions as a Tumor Suppressor and Is Regulated by DNA Methylation in Colorectal Cancer
por: Liu, Can, et al.
Publicado: (2020)

Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness
por: Ando, Tomofumi, et al.
Publicado: (2022)

Flrt2 is involved in fine-tuning of osteoclast multinucleation
por: Shirakawa, Jumpei, et al.
Publicado: (2019)

Cadherin-11 is inactivated due to promoter methylation and functions in colorectal cancer as a tumour suppressor
por: Yuan, Shiyun, et al.
Publicado: (2019)

JAM3 functions as a novel tumor suppressor and is inactivated by DNA methylation in colorectal cancer
por: Zhou, Dan, et al.
Publicado: (2019)

FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
por: Seiradake, Elena, et al.
Publicado: (2014)

Inactivation of the Hippo tumor suppressor pathway promotes melanoma
por: Vittoria, Marc A., et al.
Publicado: (2022)

A Protocadherin-Cadherin-FLRT3 Complex Controls Cell Adhesion and Morphogenesis
por: Chen, Xuejun, et al.
Publicado: (2009)

Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer
por: Guerrero-Preston, Rafael, et al.
Publicado: (2014)

Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice
por: Cicvaric, Ana, et al.
Publicado: (2018)

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
por: Jauhiainen, Suvi, et al.
Publicado: (2019)

Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury
por: Li, Juntan, et al.
Publicado: (2021)

FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus
por: Ruff, Tobias, et al.
Publicado: (2021)

PCDH18 is frequently inactivated by promoter methylation in colorectal cancer
por: Zhou, Dan, et al.
Publicado: (2017)

Unc5B Interacts with FLRT3 and Rnd1 to Modulate Cell Adhesion in Xenopus Embryos
por: Karaulanov, Emil, et al.
Publicado: (2009)

Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3
por: Heath, Robert J. W., et al.
Publicado: (2011)

Assessment of tumor suppressor promoter methylation in healthy individuals
por: Poduval, Deepak B., et al.
Publicado: (2020)

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer
por: Dopeso, Higinio, et al.
Publicado: (2018)

Promoter Hypermethylation of KLF4 Inactivates Its Tumor Suppressor Function in Cervical Carcinogenesis
por: Yang, Wen-Ting, et al.
Publicado: (2014)

MicroRNA-103 Promotes Colorectal Cancer by Targeting Tumor Suppressor DICER and PTEN
por: Geng, Li, et al.
Publicado: (2014)

Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers
por: Hu, Xiaotong, et al.
Publicado: (2017)

Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia
por: Nicot, Christophe
Publicado: (2015)

NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer
por: Luo, Yanxin, et al.
Publicado: (2013)

NK homeobox 2.2 functions as tumor suppressor in colorectal cancer due to DNA methylation
por: He, Yuan, et al.
Publicado: (2020)

Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation
por: Tao, Yan-Fang, et al.
Publicado: (2014)

The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation
por: Du, Zhenfang, et al.
Publicado: (2016)

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53
por: Malkomes, Patrizia, et al.
Publicado: (2021)

Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer
por: OuYang, Li-Ying, et al.
Publicado: (2015)

MRVI1 and NTRK3 Are Potential Tumor Suppressor Genes Commonly Inactivated by DNA Methylation in Cervical Cancer
por: Ji, Huihui, et al.
Publicado: (2022)

Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma
por: Li, Ji-Sheng, et al.
Publicado: (2013)

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review
por: Sheikholeslami, Sara, et al.
Publicado: (2021)

Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia
por: Lee, Shih-Han, et al.
Publicado: (2018)

Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors
por: Sicari, Daria, et al.
Publicado: (2021)

Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency
por: Bekas, Nikolaos, et al.
Publicado: (2023)

Quantitative Methylation Profiles for Multiple Tumor Suppressor Gene Promoters in Salivary Gland Tumors
por: Durr, Megan L., et al.
Publicado: (2010)

TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma
por: Wang, Shumin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4252bsde5rnc6t3kf7vmj9mlj1