Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies

Early developmental specification can be modeled by differentiating embryonic stem cells (ESCs) to embryoid bodies (EBs), a heterogeneous mixture of three germ layers. Here, we combine single-cell transcriptomics and genetic recording to characterize EB differentiation. We map transcriptional states...

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Detalles Bibliográficos
Autores principales: Kim, Ik Soo, Wu, Jingyi, Rahme, Gilbert J., Battaglia, Sofia, Dixit, Atray, Gaskell, Elizabeth, Chen, Huidong, Pinello, Luca, Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646252/
https://www.ncbi.nlm.nih.gov/pubmed/33027665
http://dx.doi.org/10.1016/j.celrep.2020.108222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646252/
https://www.ncbi.nlm.nih.gov/pubmed/33027665
http://dx.doi.org/10.1016/j.celrep.2020.108222

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