Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer

PURPOSE: Platinum resistance is a primary barrier to improving the survival rate of ovarian cancer. The relationship between mtDNA somatic mutations and response to platinum-based chemotherapy in ovarian cancer has not been well clarified. PATIENTS AND METHODS: Here, we employed the next-generation...

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Detalles Bibliográficos
Autores principales: Ni, Jing, Wang, Yan, Cheng, Xianzhong, Teng, Fang, Wang, Congyang, Han, Suping, Chen, Xiaoxiang, Guo, Wenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646460/
https://www.ncbi.nlm.nih.gov/pubmed/33173341
http://dx.doi.org/10.2147/CMAR.S277724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646460/
https://www.ncbi.nlm.nih.gov/pubmed/33173341
http://dx.doi.org/10.2147/CMAR.S277724

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