CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and bivalent binding to tumor-associated antigens in order to recruit and activate T-cells for tumor cell killing. In vivo, T-cell activation is u...

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Detalles Bibliográficos
Autores principales: Jost, Christian, Darowski, Diana, Challier, John, Pulko, Vesna, Hanisch, Lydia J, Xu, Wei, Mössner, Ekkehard, Bujotzek, Alexander, Klostermann, Stefan, Umana, Pablo, Kontermann, Roland E., Klein, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646475/
https://www.ncbi.nlm.nih.gov/pubmed/33136521
http://dx.doi.org/10.1080/19420862.2020.1840709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646475/
https://www.ncbi.nlm.nih.gov/pubmed/33136521
http://dx.doi.org/10.1080/19420862.2020.1840709

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