Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism

The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on infiltrating immune cells and tumor cells across a...

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Detalles Bibliográficos
Autores principales: Spatola, Bradley N., Lerner, Alana G., Wong, Clifford, dela Cruz, Tracy, Welch, Megan, Fung, Wanchi, Kovalenko, Maria, Losenkova, Karolina, Yegutkin, Gennady G., Beers, Courtney, Corbin, John, Soros, Vanessa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646477/
https://www.ncbi.nlm.nih.gov/pubmed/33146056
http://dx.doi.org/10.1080/19420862.2020.1838036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646477/
https://www.ncbi.nlm.nih.gov/pubmed/33146056
http://dx.doi.org/10.1080/19420862.2020.1838036

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