Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants

The autoimmune disease known as Jo-1 positive anti-synthetase syndrome (ASS) is characterized by circulating antibody titers to histidyl-tRNA synthetase (HARS), which may play a role in modulating the non-canonical functions of HARS. Monoclonal antibodies to HARS were isolated by single-cell screeni...

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Detalles Bibliográficos
Autores principales: Burman, Luke, Chong, Yeeting E., Duncan, Sherie, Klaus, Anders, Rauch, Kaitlyn, Hamel, Kristina, Hervé, Karine, Pfaffen, Stephanie, Collins, David W., Heyries, Kevin, Nangle, Leslie, Hansen, Carl, King, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646482/
https://www.ncbi.nlm.nih.gov/pubmed/33131414
http://dx.doi.org/10.1080/19420862.2020.1836718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646482/
https://www.ncbi.nlm.nih.gov/pubmed/33131414
http://dx.doi.org/10.1080/19420862.2020.1836718

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