Cargando…

Butyrate enhances the efficacy of radiotherapy via FOXO3A in colorectal cancer patient-derived organoids

Enhancing the radioresponsiveness of colorectal cancer (CRC) is essential for local control and prognosis. However, consequent damage to surrounding healthy cells can lead to treatment failure. We hypothesized that short-chain fatty acids (SCFAs) could act as radiosensitizers for cancer cells, allow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Misun, Kwon, Junhye, Shin, Hye-Jin, Moon, Sun Mi, Kim, Sang Bum, Shin, Ui Sup, Han, Young-Hoon, Kim, Younjoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646587/ https://www.ncbi.nlm.nih.gov/pubmed/33173975 http://dx.doi.org/10.3892/ijo.2020.5132

Ejemplares similares

A Patient-Derived Organoid-Based Radiosensitivity Model for the Prediction of Radiation Responses in Patients with Rectal Cancer
por: Park, Misun, et al.
Publicado: (2021)

Advanced Xenograft Model with Cotransplantation of Patient-Derived Organoids and Endothelial Colony-Forming Cells for Precision Medicine
por: Kwon, Junhye, et al.
Publicado: (2021)

Stimulatory Anticancer Effect of Resveratrol Mediated by G Protein-Coupled Estrogen Receptor in Colorectal Cancer
por: Kim, Nayun, et al.
Publicado: (2023)

Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer
por: Lee, Jeeyong, et al.
Publicado: (2021)

Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
por: Lee, Jong Il, et al.
Publicado: (2021)

IGFL2-AS1, a Long Non-Coding RNA, Is Associated with Radioresistance in Colorectal Cancer
por: Lee, Jeeyong, et al.
Publicado: (2023)

Immunogenicity of Influenza Vaccine in Colorectal Cancer Patients
por: Kim, Dong Ho, et al.
Publicado: (2013)

Promoter methylation of cysteine dioxygenase type 1: gene silencing and tumorigenesis in hepatocellular carcinoma
por: Choi, Jung-il, et al.
Publicado: (2017)

The Impact of Primary Tumor Resection on Survival in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases
por: Doah, Ki Yoon, et al.
Publicado: (2021)

5-Fluorouracil as a Tumor-Treating Field-Sensitizer in Colon Cancer Therapy
por: Lee, Yeon-Joo, et al.
Publicado: (2019)

Role of Peritoneal Lavage Cytology and Prediction of Prognosis and Peritoneal Recurrence After Curative Surgery for Colorectal Cancer
por: Bae, Sung Joon, et al.
Publicado: (2014)

MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin
por: Park, Misun, et al.
Publicado: (2017)

Early Detection of Secondary Bladder Urothelial Carcinoma and Disseminated Bone Metastases with Normal Prostate-Specific Antigen Level after Pelvic Salvage Radiotherapy in Prostate Cancer
por: Shin, Teak Jun, et al.
Publicado: (2023)

Impact on Prognosis of Lymph Node Micrometastasis and Isolated Tumor Cells in Stage II Colorectal Cancer
por: Oh, Tai Young, et al.
Publicado: (2011)

Clinical outcomes of locking polymeric clip for laparoscopic appendectomy in patients with appendicitis: a retrospective comparison with loop ligature
por: Kim, Seokwon, et al.
Publicado: (2022)

Is Microsatellite Instability Really a Good Prognostic Factor of Colorectal Cancer?
por: Shin, Ui Sup, et al.
Publicado: (2014)

FOXO inhibition rescues α-defensin expression in human intestinal organoids
por: Eng, Serena J., et al.
Publicado: (2023)

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics
por: Singh, Vineet, et al.
Publicado: (2023)

Covered Metallic Stents With an Anti-Migration Design vs. Uncovered Stents for the Palliation of Malignant Gastric Outlet Obstruction: A Multicenter, Randomized Trial
por: Lee, Hyuk, et al.
Publicado: (2015)

Simulated microgravity inhibits C2C12 myogenesis via phospholipase D2-induced Akt/FOXO1 regulation
por: Baek, Mi-Ock, et al.
Publicado: (2019)

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients
por: Kong, JungHo, et al.
Publicado: (2020)

Incidence and Risk Factors of Parastomal Hernia
por: Sohn, Yeun Ju, et al.
Publicado: (2012)

Organoids and Colorectal Cancer
por: Barbáchano, Antonio, et al.
Publicado: (2021)

Neutrophil to Lymphocyte Ratio: A Predictive Marker for Treatment Outcomes in Patients With Rectal Cancer Who Underwent Neoadjuvant Chemoradiation Followed by Surgery
por: Jeon, Byong Ho, et al.
Publicado: (2019)

A Patient With a Progressive Cecal Subepithelial Tumor
por: Kim, Younjoo
Publicado: (2015)

Can Umbilical Cord Mesenchymal Stem Cells Treatment Be a Hope for Patients with Refractory Crohn’s Disease?
por: Kim, Younjoo
Publicado: (2018)

Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer?
por: Jung, Myung-Kyu, et al.
Publicado: (2017)

Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression
por: Lee, Hae June, et al.
Publicado: (2019)

Synergistic effect of sodium butyrate and oxaliplatin on colorectal cancer
por: Shuwen, Han, et al.
Publicado: (2022)

FOXO1 Inhibition Yields Functional Insulin-Producing Cells In Human Gut Organoid Cultures
por: Bouchi, Ryotaro, et al.
Publicado: (2014)

Advances of Patient-Derived Organoids in Personalized Radiotherapy
por: Wang, Yuenan, et al.
Publicado: (2022)

Effectiveness of Adjuvant Chemotherapy with 5-FU/Leucovorin and Prognosis in Stage II Colon Cancer
por: Jee, Sun Hee, et al.
Publicado: (2011)

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells
por: Kim, Da Som, et al.
Publicado: (2018)

Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor
por: Han, Sung-Hoon, et al.
Publicado: (2017)

Quantitative and Qualitative Analysis of Neurotransmitter and Neurosteroid Production in Cerebral Organoids during Differentiation
por: Park, Sung Bum, et al.
Publicado: (2023)

Modelling Toxoplasma gondii infection in human cerebral organoids
por: Seo, Hyang-Hee, et al.
Publicado: (2020)

Evaluation of the dosimetric and radiobiological parameters in four radiotherapy regimens for synchronous bilateral breast cancer
por: Kang, Sang‐Won, et al.
Publicado: (2022)

Feasibility of Ultra-Thin Fiber-Optic Dosimeters for Radiotherapy Dosimetry
por: Lee, Bongsoo, et al.
Publicado: (2015)

Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
por: Wu, Xinqiang, et al.
Publicado: (2018)

Sodium butyrate in both prevention and supportive treatment of colorectal cancer
por: Kaźmierczak-Siedlecka, Karolina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tj0dt17ip4m25joh7i4dm2396d