Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QT(C) prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine product BUTRANS(®). Because Q...

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Detalles Bibliográficos
Autores principales: Tran, Phu N., Sheng, Jiansong, Randolph, Aaron L., Baron, Claudia Alvarez, Thiebaud, Nicolas, Ren, Ming, Wu, Min, Johannesen, Lars, Volpe, Donna A., Patel, Dakshesh, Blinova, Ksenia, Strauss, David G., Wu, Wendy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647070/
https://www.ncbi.nlm.nih.gov/pubmed/33157550
http://dx.doi.org/10.1371/journal.pone.0241362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647070/
https://www.ncbi.nlm.nih.gov/pubmed/33157550
http://dx.doi.org/10.1371/journal.pone.0241362

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