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Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted function, undermining fundamental understanding of pathogenicity and drug susceptibility. To address this challenge, we developed a high-throughput functional genomics approach combining inducible CRISPR-interferenc...

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Detalles Bibliográficos
Autores principales:	de Wet, Timothy J, Winkler, Kristy R, Mhlanga, Musa, Mizrahi, Valerie, Warner, Digby F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647400/ https://www.ncbi.nlm.nih.gov/pubmed/33155979 http://dx.doi.org/10.7554/eLife.60083

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