SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate (THF), whose production by the enzyme DHFR is targeted by the important anticancer drug methotrexate. 1C units come largely from serine catabolism by the...

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Detalles Bibliográficos
Autores principales: García-Cañaveras, Juan C., Lancho, Olga, Ducker, Gregory S., Ghergurovich, Jonathan M., Xu, Xincheng, da Silva-Diz, Victoria, Minuzzo, Sonia, Indraccolo, Stefano, Kim, Hahn, Herranz, Daniel, Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647950/
https://www.ncbi.nlm.nih.gov/pubmed/32382081
http://dx.doi.org/10.1038/s41375-020-0845-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647950/
https://www.ncbi.nlm.nih.gov/pubmed/32382081
http://dx.doi.org/10.1038/s41375-020-0845-6

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