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Development of adoptive immunotherapy with KK‐LC‐1‐specific TCR‐transduced γδT cells against lung cancer cells

The present study analyzed the antitumor effect of γδT cells transduced with the TCR of cancer‐specific CTLs to establish forceful cancer‐specific adoptive immunotherapy. We cloned the TCRαβ genes from CTLs showing HLA‐B15 restricted recognition of Kita‐Kyushu lung cancer antigen‐1 (KK‐LC‐1), a canc...

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Detalles Bibliográficos
Autores principales: Ichiki, Yoshinobu, Shigematsu, Yoshiki, Baba, Tetsuro, Shiota, Hironobu, Fukuyama, Takashi, Nagata, Yoshika, So, Tetsuya, Yasuda, Manabu, Takenoyama, Mitsuhiro, Yasumoto, Kosei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648040/
https://www.ncbi.nlm.nih.gov/pubmed/32780528
http://dx.doi.org/10.1111/cas.14612