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Comparative analysis of differentially abundant proteins quantified by LC–MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples

BACKGROUND: Proteomic studies are typically conducted using flash-frozen (FF) samples utilizing tandem mass spectrometry (MS). However, FF specimens are comprised of multiple cell types, making it difficult to ascertain the proteomic profiles of specific cells. Conversely, OCT-embedded (Optimal Cutt...

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Detalles Bibliográficos
Autores principales: Sturtz, Lori A., Wang, Guisong, Shah, Punit, Searfoss, Richard, Raj-Kumar, Praveen-Kumar, Hooke, Jeffrey A., Fantacone-Campbell, J. Leigh, Deyarmin, Brenda, Cutler, Mary Lou, Sarangarajan, Rangaprasad, Narain, Niven R., Hu, Hai, Kiebish, Michael A., Kovatich, Albert J., Shriver, Craig D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648272/
https://www.ncbi.nlm.nih.gov/pubmed/33292179
http://dx.doi.org/10.1186/s12014-020-09300-y