Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

BACKGROUND: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that dir...

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Detalles Bibliográficos
Autores principales: Liu, Xiao-ge, Zhang, Lun, Lu, Shuai, Liu, Dong-qun, Huang, Ya-ru, Zhu, Jie, Zhou, Wei-wei, Yu, Xiao-lin, Liu, Rui-tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648289/
https://www.ncbi.nlm.nih.gov/pubmed/33160377
http://dx.doi.org/10.1186/s12951-020-00723-1

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