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Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans

CRISPR genome editing has revolutionized genetics in many organisms. In the nematode Caenorhabditis elegans, one injection into each of the two gonad arms of an adult hermaphrodite exposes hundreds of meiotic germ cells to editing mixtures, permitting the recovery of multiple indels or small precisi...

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Detalles Bibliográficos
Autores principales: Ghanta, Krishna S., Mello, Craig C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648581/
https://www.ncbi.nlm.nih.gov/pubmed/32963112
http://dx.doi.org/10.1534/genetics.120.303564