Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo

Slit is a secreted protein that has a canonical function of repelling growing axons from the CNS midline. The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have potentially distinct functions via different receptors. Here, we report that the BMP-1/Tolloid family metal...

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Detalles Bibliográficos
Autores principales: Kellermeyer, Riley, Heydman, Leah M., Gillis, Taylor, Mastick, Grant S., Song, Minmin, Kidd, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648596/
https://www.ncbi.nlm.nih.gov/pubmed/32994163
http://dx.doi.org/10.1242/dev.196055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648596/
https://www.ncbi.nlm.nih.gov/pubmed/32994163
http://dx.doi.org/10.1242/dev.196055

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