TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

TAR DNA-binding protein 43 (TDP-43; also known as TARDBP) is an RNA-binding protein whose aggregation is a hallmark of the neurodegenerative disorders amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43 loss increases DNA damage and compromises cell viability, but the actual function o...

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Detalles Bibliográficos
Autores principales: Wood, Matthew, Quinet, Annabel, Lin, Yea-Lih, Davis, Albert A., Pasero, Philippe, Ayala, Yuna M., Vindigni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648616/
https://www.ncbi.nlm.nih.gov/pubmed/32989039
http://dx.doi.org/10.1242/jcs.244129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648616/
https://www.ncbi.nlm.nih.gov/pubmed/32989039
http://dx.doi.org/10.1242/jcs.244129

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