SYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism

Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML) maintenance and progression. Genetic or pharmacologic inhibition of SYK in AML cells leads to increased differentiation, reduced proliferation, an...

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Detalles Bibliográficos
Autores principales: Polak, Anna, Bialopiotrowicz, Emilia, Krzymieniewska, Beata, Wozniak, Jolanta, Stojak, Marta, Cybulska, Magdalena, Kaniuga, Ewelina, Mikula, Michał, Jablonska, Ewa, Gorniak, Patryk, Noyszewska-Kania, Monika, Szydlowski, Maciej, Piechna, Karolina, Piwocka, Katarzyna, Bugajski, Lukasz, Lech-Maranda, Ewa, Barankiewicz, Joanna, Kolkowska-Lesniak, Agnieszka, Patkowska, Elzbieta, Glodkowska-Mrowka, Eliza, Baran, Natalia, Juszczynski, Przemyslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648638/
https://www.ncbi.nlm.nih.gov/pubmed/33159047
http://dx.doi.org/10.1038/s41419-020-03156-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648638/
https://www.ncbi.nlm.nih.gov/pubmed/33159047
http://dx.doi.org/10.1038/s41419-020-03156-8

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