HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

BACKGROUND: Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). However, it is unknown whether pyroptosis participates in the development of CAC. MET...

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Detalles Bibliográficos
Autores principales: Tan, Gao, Huang, Chongyang, Chen, Jiaye, Zhi, Fachao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648939/
https://www.ncbi.nlm.nih.gov/pubmed/33160389
http://dx.doi.org/10.1186/s13045-020-00985-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648939/
https://www.ncbi.nlm.nih.gov/pubmed/33160389
http://dx.doi.org/10.1186/s13045-020-00985-0

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