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HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

BACKGROUND: Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). However, it is unknown whether pyroptosis participates in the development of CAC. MET...

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Detalles Bibliográficos
Autores principales:	Tan, Gao, Huang, Chongyang, Chen, Jiaye, Zhi, Fachao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648939/ https://www.ncbi.nlm.nih.gov/pubmed/33160389 http://dx.doi.org/10.1186/s13045-020-00985-0

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