Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

BACKGROUND: Perioperative neurocognitive disorders (PNDs) occur frequently after surgery and worsen patient outcome. How C-X-C motif chemokine (CXCL) 13 and its sole receptor CXCR5 contribute to PNDs remains poorly understood. METHODS: A PND model was created in adult male C57BL/6J and CXCR5(−/−) mi...

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Detalles Bibliográficos
Autores principales: Shen, Yanan, Zhang, Yuan, Chen, Lihai, Du, Jiayue, Bao, Hongguang, Xing, Yan, Cai, Mengmeng, Si, Yanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648984/
https://www.ncbi.nlm.nih.gov/pubmed/33161894
http://dx.doi.org/10.1186/s12974-020-02013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648984/
https://www.ncbi.nlm.nih.gov/pubmed/33161894
http://dx.doi.org/10.1186/s12974-020-02013-x

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