Cargando…

Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

BACKGROUND: Perioperative neurocognitive disorders (PNDs) occur frequently after surgery and worsen patient outcome. How C-X-C motif chemokine (CXCL) 13 and its sole receptor CXCR5 contribute to PNDs remains poorly understood. METHODS: A PND model was created in adult male C57BL/6J and CXCR5(−/−) mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Yanan, Zhang, Yuan, Chen, Lihai, Du, Jiayue, Bao, Hongguang, Xing, Yan, Cai, Mengmeng, Si, Yanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648984/ https://www.ncbi.nlm.nih.gov/pubmed/33161894 http://dx.doi.org/10.1186/s12974-020-02013-x

Ejemplares similares

Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice
por: Zhang, Qian, et al.
Publicado: (2016)

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice
por: Si, Yanna, et al.
Publicado: (2016)

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
por: Shi, Yi, et al.
Publicado: (2020)

The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF
por: Harrer, Christine, et al.
Publicado: (2021)

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
por: Collins, Paul J., et al.
Publicado: (2017)

The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16
por: Adamski, Vivian, et al.
Publicado: (2017)

CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms
por: Xiao, Gang, et al.
Publicado: (2015)

Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma
por: Guo, Li, et al.
Publicado: (2011)

Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma
por: Widney, Daniel P., et al.
Publicado: (2010)

Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma
por: Widney, DP, et al.
Publicado: (2009)

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
por: Döring, Yvonne, et al.
Publicado: (2014)

CXCL9-11 chemokines and CXCR3 receptor in teleost fish species
por: Valdés, Natalia, et al.
Publicado: (2022)

Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells
por: Bronger, Holger, et al.
Publicado: (2017)

CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway
por: Shen, Yanan, et al.
Publicado: (2021)

CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE
por: Da, Zhanyun, et al.
Publicado: (2016)

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis
por: Zielińska, Karolina A., et al.
Publicado: (2020)

Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells
por: Heinrich, Eileen L, et al.
Publicado: (2012)

The expression and biological function of chemokine CXCL12 and receptor CXCR4/CXCR7 in placenta accreta spectrum disorders
por: Long, Yu, et al.
Publicado: (2020)

Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
por: Lv, Yunfu, et al.
Publicado: (2023)

Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases
por: Pan, Zijian, et al.
Publicado: (2022)

Impact of edaravone on serum CXC chemokine ligand-13 levels and perioperative neurocognitive disorders in elderly patients with hip replacement
por: Xie, Hai-Hui, et al.
Publicado: (2021)

The Chemokine CXCL16 and Its Receptor, CXCR6, as Markers and Promoters of Inflammation-Associated Cancers
por: Darash-Yahana, Merav, et al.
Publicado: (2009)

Chemokine Receptor CXCR7 Is a Functional Receptor for CXCL12 in Brain Endothelial Cells
por: Liu, Yang, et al.
Publicado: (2014)

Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
por: Brown, Aaron J., et al.
Publicado: (2017)

Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders
por: He, Keqiang, et al.
Publicado: (2022)

The chemokine CXCL13 is elevated in the cerebrospinal fluid of patients with neurosyphilis
por: Dersch, R, et al.
Publicado: (2015)

The chemokine CXCL13 in cerebrospinal fluid in children with Lyme neuroborreliosis
por: Henningsson, Anna J., et al.
Publicado: (2018)

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3
por: Nedjai, Belinda, et al.
Publicado: (2012)

EBV‐positive pyothorax‐associated lymphoma expresses CXCL9 and CXCL10 chemokines that attract cytotoxic lymphocytes via CXCR3
por: Higuchi, Tomonori, et al.
Publicado: (2023)

Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment
por: Tan, Ping, et al.
Publicado: (2018)

Corrigendum: Role of the CXCL13/CXCR5 axis in autoimmune diseases
por: Pan, Zijian, et al.
Publicado: (2022)

The ELR(+)CXCL chemokines and their receptors CXCR1/CXCR2: A signaling axis and new target for the treatment of renal cell carcinoma
por: Giuliano, Sandy, et al.
Publicado: (2014)

Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking
por: Joseph, Prem Raj B., et al.
Publicado: (2017)

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation
por: Mines, Marjelo A., et al.
Publicado: (2009)

Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
por: Zhang, Shiwu, et al.
Publicado: (2008)

The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
por: Ashley, Ryan L, et al.
Publicado: (2011)

The Serum Concentrations of Chemokine CXCL12 and Its Specific Receptor CXCR4 in Patients with Esophageal Cancer
por: Łukaszewicz-Zając, Marta, et al.
Publicado: (2016)

Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer
por: Benhadjeba, Samira, et al.
Publicado: (2018)

Immunohistochemical Expression of Chemokine Receptor CXCR3 and its Ligand CXCL 11 in Basal Cell Carcinoma
por: Ansari, Mariya K., et al.
Publicado: (2023)

mTOR‐mediated autophagy in the hippocampus is involved in perioperative neurocognitive disorders in diabetic rats
por: Chen, Xiaohui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ka47tidt37esq5odpifl728l5g