The role of m(6)A modification in physiology and disease

Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m(6)A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RN...

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Autores principales: Yang, Chuan, Hu, Yiyang, Zhou, Bo, Bao, Yulu, Li, Zhibin, Gong, Chunli, Yang, Huan, Wang, Sumin, Xiao, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649148/
https://www.ncbi.nlm.nih.gov/pubmed/33162550
http://dx.doi.org/10.1038/s41419-020-03143-z
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author Yang, Chuan
Hu, Yiyang
Zhou, Bo
Bao, Yulu
Li, Zhibin
Gong, Chunli
Yang, Huan
Wang, Sumin
Xiao, Yufeng
author_facet Yang, Chuan
Hu, Yiyang
Zhou, Bo
Bao, Yulu
Li, Zhibin
Gong, Chunli
Yang, Huan
Wang, Sumin
Xiao, Yufeng
author_sort Yang, Chuan
collection PubMed
description Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m(6)A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) proteins, and is recognized by reader (m(6)A-binding) proteins. The effects of m(6)A modification are reflected in the functional modulation of mRNA splicing, export, localization, translation, and stability by regulating RNA structure and interactions between RNA and RNA-binding proteins. This modulation is involved in a variety of physiological behaviors, including neurodevelopment, immunoregulation, and cellular differentiation. The disruption of m(6)A modulations impairs gene expression and cellular function and ultimately leads to diseases such as cancer, psychiatric disorders, and metabolic disease. This review focuses on the mechanisms and functions of m(6)A modification in a variety of physiological behaviors and diseases.
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spelling pubmed-76491482020-11-10 The role of m(6)A modification in physiology and disease Yang, Chuan Hu, Yiyang Zhou, Bo Bao, Yulu Li, Zhibin Gong, Chunli Yang, Huan Wang, Sumin Xiao, Yufeng Cell Death Dis Review Article Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m(6)A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) proteins, and is recognized by reader (m(6)A-binding) proteins. The effects of m(6)A modification are reflected in the functional modulation of mRNA splicing, export, localization, translation, and stability by regulating RNA structure and interactions between RNA and RNA-binding proteins. This modulation is involved in a variety of physiological behaviors, including neurodevelopment, immunoregulation, and cellular differentiation. The disruption of m(6)A modulations impairs gene expression and cellular function and ultimately leads to diseases such as cancer, psychiatric disorders, and metabolic disease. This review focuses on the mechanisms and functions of m(6)A modification in a variety of physiological behaviors and diseases. Nature Publishing Group UK 2020-11-08 /pmc/articles/PMC7649148/ /pubmed/33162550 http://dx.doi.org/10.1038/s41419-020-03143-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yang, Chuan
Hu, Yiyang
Zhou, Bo
Bao, Yulu
Li, Zhibin
Gong, Chunli
Yang, Huan
Wang, Sumin
Xiao, Yufeng
The role of m(6)A modification in physiology and disease
title The role of m(6)A modification in physiology and disease
title_full The role of m(6)A modification in physiology and disease
title_fullStr The role of m(6)A modification in physiology and disease
title_full_unstemmed The role of m(6)A modification in physiology and disease
title_short The role of m(6)A modification in physiology and disease
title_sort role of m(6)a modification in physiology and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649148/
https://www.ncbi.nlm.nih.gov/pubmed/33162550
http://dx.doi.org/10.1038/s41419-020-03143-z
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