Novel oral anticoagulants in intracardiac thrombosis resolution: a case series

BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Sadawi, Mohammed, Francois, Jonathan, Rodriguez Ortega, Romy, Capric, Violeta, Budzikowski, Adam S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649461/
https://www.ncbi.nlm.nih.gov/pubmed/33204959
http://dx.doi.org/10.1093/ehjcr/ytaa181
_version_ 1783607333174116352
author Al-Sadawi, Mohammed
Francois, Jonathan
Rodriguez Ortega, Romy
Capric, Violeta
Budzikowski, Adam S
author_facet Al-Sadawi, Mohammed
Francois, Jonathan
Rodriguez Ortega, Romy
Capric, Violeta
Budzikowski, Adam S
author_sort Al-Sadawi, Mohammed
collection PubMed
description BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for intracardiac thrombosis. Although limited, there is growing evidence that DOACs are effective for intracardiac thrombosis and some data suggest that thrombus resolution might be superior to that with warfarin. CASE SUMMARY: Here, we present a series of six patients with left atrial appendage thrombi were treated with a venous thromboembolic dose of DOACs with resolution within 2–6 months with no reported complications. DISCUSSION: This case series adds to the accumulating evidence supporting the efficacy of DOACs in the treatment of intracardiac thrombi.
format Online
Article
Text
id pubmed-7649461
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-76494612020-11-16 Novel oral anticoagulants in intracardiac thrombosis resolution: a case series Al-Sadawi, Mohammed Francois, Jonathan Rodriguez Ortega, Romy Capric, Violeta Budzikowski, Adam S Eur Heart J Case Rep Case Series BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for intracardiac thrombosis. Although limited, there is growing evidence that DOACs are effective for intracardiac thrombosis and some data suggest that thrombus resolution might be superior to that with warfarin. CASE SUMMARY: Here, we present a series of six patients with left atrial appendage thrombi were treated with a venous thromboembolic dose of DOACs with resolution within 2–6 months with no reported complications. DISCUSSION: This case series adds to the accumulating evidence supporting the efficacy of DOACs in the treatment of intracardiac thrombi. Oxford University Press 2020-08-30 /pmc/articles/PMC7649461/ /pubmed/33204959 http://dx.doi.org/10.1093/ehjcr/ytaa181 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Series
Al-Sadawi, Mohammed
Francois, Jonathan
Rodriguez Ortega, Romy
Capric, Violeta
Budzikowski, Adam S
Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title_full Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title_fullStr Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title_full_unstemmed Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title_short Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
title_sort novel oral anticoagulants in intracardiac thrombosis resolution: a case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649461/
https://www.ncbi.nlm.nih.gov/pubmed/33204959
http://dx.doi.org/10.1093/ehjcr/ytaa181
work_keys_str_mv AT alsadawimohammed noveloralanticoagulantsinintracardiacthrombosisresolutionacaseseries
AT francoisjonathan noveloralanticoagulantsinintracardiacthrombosisresolutionacaseseries
AT rodriguezortegaromy noveloralanticoagulantsinintracardiacthrombosisresolutionacaseseries
AT capricvioleta noveloralanticoagulantsinintracardiacthrombosisresolutionacaseseries
AT budzikowskiadams noveloralanticoagulantsinintracardiacthrombosisresolutionacaseseries