Novel oral anticoagulants in intracardiac thrombosis resolution: a case series
BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649461/ https://www.ncbi.nlm.nih.gov/pubmed/33204959 http://dx.doi.org/10.1093/ehjcr/ytaa181 |
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author | Al-Sadawi, Mohammed Francois, Jonathan Rodriguez Ortega, Romy Capric, Violeta Budzikowski, Adam S |
author_facet | Al-Sadawi, Mohammed Francois, Jonathan Rodriguez Ortega, Romy Capric, Violeta Budzikowski, Adam S |
author_sort | Al-Sadawi, Mohammed |
collection | PubMed |
description | BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for intracardiac thrombosis. Although limited, there is growing evidence that DOACs are effective for intracardiac thrombosis and some data suggest that thrombus resolution might be superior to that with warfarin. CASE SUMMARY: Here, we present a series of six patients with left atrial appendage thrombi were treated with a venous thromboembolic dose of DOACs with resolution within 2–6 months with no reported complications. DISCUSSION: This case series adds to the accumulating evidence supporting the efficacy of DOACs in the treatment of intracardiac thrombi. |
format | Online Article Text |
id | pubmed-7649461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-76494612020-11-16 Novel oral anticoagulants in intracardiac thrombosis resolution: a case series Al-Sadawi, Mohammed Francois, Jonathan Rodriguez Ortega, Romy Capric, Violeta Budzikowski, Adam S Eur Heart J Case Rep Case Series BACKGROUND: Vitamin K antagonists (VKAs) have been regarded as the therapy of choice for intracardiac thrombosis for decades based mostly on observational data. The advent of direct oral anticoagulants (DOACs) has displaced VKAs as the first-line therapy for multiple thrombotic disorders but not for intracardiac thrombosis. Although limited, there is growing evidence that DOACs are effective for intracardiac thrombosis and some data suggest that thrombus resolution might be superior to that with warfarin. CASE SUMMARY: Here, we present a series of six patients with left atrial appendage thrombi were treated with a venous thromboembolic dose of DOACs with resolution within 2–6 months with no reported complications. DISCUSSION: This case series adds to the accumulating evidence supporting the efficacy of DOACs in the treatment of intracardiac thrombi. Oxford University Press 2020-08-30 /pmc/articles/PMC7649461/ /pubmed/33204959 http://dx.doi.org/10.1093/ehjcr/ytaa181 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Series Al-Sadawi, Mohammed Francois, Jonathan Rodriguez Ortega, Romy Capric, Violeta Budzikowski, Adam S Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title | Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title_full | Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title_fullStr | Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title_full_unstemmed | Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title_short | Novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
title_sort | novel oral anticoagulants in intracardiac thrombosis resolution: a case series |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649461/ https://www.ncbi.nlm.nih.gov/pubmed/33204959 http://dx.doi.org/10.1093/ehjcr/ytaa181 |
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