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Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces

Interactions between their transmembrane domains (TMDs) frequently support the assembly of single-pass membrane proteins to non-covalent complexes. Yet, the TMD-TMD interactome remains largely uncharted. With a view to predicting homotypic TMD-TMD interfaces from primary structure, we performed a sy...

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Detalles Bibliográficos
Autores principales: Xiao, Yao, Zeng, Bo, Berner, Nicola, Frishman, Dmitrij, Langosch, Dieter, Teese, Mark George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649602/
https://www.ncbi.nlm.nih.gov/pubmed/33209210
http://dx.doi.org/10.1016/j.csbj.2020.09.035