OGT-Mediated KEAP1 Glycosylation Accelerates NRF2 Degradation Leading to High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease

Unraveling the complex regulatory pathways that mediate the effects of phosphate on vascular smooth muscle cells (VSMCs) may provide novel targets and therapies to limit the destructive effects of vascular calcification (VC) in patients with chronic kidney disease (CKD). Our previous studies have hi...

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Detalles Bibliográficos
Autores principales: Xu, Tian-Hua, Du, Yinke, Sheng, Zitong, Li, Yue, Qiu, Xiaobo, Tian, Binyao, Yao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649800/
https://www.ncbi.nlm.nih.gov/pubmed/33192538
http://dx.doi.org/10.3389/fphys.2020.01092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649800/
https://www.ncbi.nlm.nih.gov/pubmed/33192538
http://dx.doi.org/10.3389/fphys.2020.01092

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